Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro.

  title={Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro.},
  author={Charles A Dinarello and Robert A. Thompson},
  journal={Immunology today},
  volume={12 11},
Clinical and experimental evidence suggests that shock, arthritis, osteoporosis, colitis, leukemia, diabetes, wasting and atherosclerosis are mediated, in part, by interleukin 1 (IL-1). Inhibition of this cytokine has been a strategy for studying disease and for new drug development. A naturally-occurring IL-1 inhibitor (IL-1 receptor antagonist, IL-1ra) that blocks binding of IL-1 to its receptors has been cloned and produced in recombinant organisms. IL-1ra reduces the severity of sepsis… CONTINUE READING
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