Blocking EGFR in the liver improves the tumor-to-liver uptake ratio of radiolabeled EGF

@article{Kareem2009BlockingEI,
  title={Blocking EGFR in the liver improves the tumor-to-liver uptake ratio of radiolabeled EGF},
  author={Heewa Kareem and Karl Sandstr{\"o}m and Ronny Elia and Lars Gedda and Matti Anniko and Hans Lundqvist and Marika Nestor},
  journal={Tumor Biology},
  year={2009},
  volume={31},
  pages={79-87}
}
Overexpression of epidermal growth factor receptor (EGFR) in several types of malignant tumors correlates with disease progression. EGFR could, therefore, be an excellent candidate for targeted radionuclide diagnostics. However, the high natural expression of EGFR in the liver may be problematic. The aim of this study was to improve the tumor-to-liver ratio of radiolabeled epidermal growth factor (EGF) by blocking its uptake by the liver with a nonradiolabeled EGFR-targeting molecule in tumor… CONTINUE READING
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