Blocking α5β1 Integrin Attenuates sCD40L-Mediated Platelet Activation.

Abstract

The soluble form of CD40L (sCD40L) is a platelet-derived mediator that links inflammation, hemostasis, and vascular dysfunction. Indeed, blockade of CD40L by neutralizing antibodies or genetic disruption in mice prevents atherosclerosis and atherothrombosis. Until recently, it was believed that CD40 and αIIbβ3 were the only receptors on platelets… (More)
DOI: 10.1177/1076029615624549

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Cite this paper

@article{imi2017BlockingI, title={Blocking α5β1 Integrin Attenuates sCD40L-Mediated Platelet Activation.}, author={Damir {\vS}imi{\'c} and Nancy J Bogdan and Fang Teng and Monicah A. Otieno}, journal={Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis}, year={2017}, volume={23 6}, pages={607-614} }