Blocker State Dependence and Trapping in Hyperpolarization-Activated Cation Channels

@article{Shin2001BlockerSD,
  title={Blocker State Dependence and Trapping in Hyperpolarization-Activated Cation Channels},
  author={Ki Soon Shin and Brad S Rothberg and Gary Yellen},
  journal={The Journal of General Physiology},
  year={2001},
  volume={117},
  pages={91 - 102}
}
Hyperpolarization-activated cation currents (I(h)) are key determinants of repetitive electrical activity in heart and nerve cells. The bradycardic agent ZD7288 is a selective blocker of these currents. We studied the mechanism for ZD7288 blockade of cloned I(h) channels in excised inside-out patches. ZD7288 blockade of the mammalian mHCN1 channel appeared to require opening of the channel, but strong hyperpolarization disfavored blockade. The steepness of this voltage-dependent effect (an… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 31 references

A bradycardic agent ZD 7288 blocks the hyperpolarization - activated current ( Ih ) in retinal rod photoreceptors

  • A. Aruffo
  • Neuropharmacol .
  • 2000

Molecular characterization of a slowly gating human hyperpolarization - activated channel predominantly expressed in thalamus , heart , and testis

  • Z. Lu
  • Proc . Natl Acad . Sci . USA .
  • 1999

Molecular characterization of the hyperpolarization - activated cation channel in rabbit heart sinoatrial node

  • M. E. Martenson, T. K. Baumann
  • J . Biol . Chem .
  • 1999

A family of hyperpolarization - activated mammalian cation channels

  • X. Zong, R. Hullin, F. Hoffmann, M. Biel
  • 1998

Molecular identification of a hyperpolarization - activated channel in sea urchin sperm

  • S. Miyazaki
  • Nature .
  • 1998

The structure of the potassium channel : molecular basis of K + conduction and selectivity

  • K. D. Black
  • Science .
  • 1998

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