Blocked autophagy using lysosomotropic agents sensitizes resistant prostate tumor cells to the novel Akt inhibitor AZD5363.

@article{Lamoureux2013BlockedAU,
  title={Blocked autophagy using lysosomotropic agents sensitizes resistant prostate tumor cells to the novel Akt inhibitor AZD5363.},
  author={François Lamoureux and Christian Thomas and Claire Crafter and Masafumi Kumano and Fan Zhang and Barry R. Davies and Martin E. Gleave and Amina Zoubeidi},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2013},
  volume={19 4},
  pages={833-44}
}
PURPOSE Prostate cancer development is often associated with deletion or silencing of tumor suppressor phosphatase and tensin homolog (PTEN), a negative regulator of the phosphoinositide 3 kinase (PI3K)-Akt pathway, leading to resistance to various therapies in both the preclinical and clinical setting. Therefore, the PI3K-Akt pathway plays a central role… CONTINUE READING