Blockage of glycolysis by targeting PFKFB3 alleviates sepsis-related acute lung injury via suppressing inflammation and apoptosis of alveolar epithelial cells.

@article{Gong2017BlockageOG,
  title={Blockage of glycolysis by targeting PFKFB3 alleviates sepsis-related acute lung injury via suppressing inflammation and apoptosis of alveolar epithelial cells.},
  author={Yuanqi Gong and Haibing Lan and Zhihong Yu and Meng Wang and Shu Wang and Yu Chen and Haiwei Rao and Jingying Li and Zhiyong Sheng and Jianghua Shao},
  journal={Biochemical and biophysical research communications},
  year={2017},
  volume={491 2},
  pages={522-529}
}
Sepsis-related acute lung injury (ALI) is characterized by excessive lung inflammation and apoptosis of alveolar epithelial cells resulting in acute hypoxemic respiratory failure. Recent studies indicated that anaerobic glycolysis play an important role in sepsis. However, whether inhibition of aerobic glycolysis exhibits beneficial effect on sepsis-induced… CONTINUE READING