Blockage of P2X7 attenuates acute lung injury in mice by inhibiting NLRP3 inflammasome.

@article{Wang2015BlockageOP,
  title={Blockage of P2X7 attenuates acute lung injury in mice by inhibiting NLRP3 inflammasome.},
  author={Shuang Wang and Jijun Zhao and Hongyue Wang and Yingjie Liang and Niansheng Yang and Yuefang Huang},
  journal={International immunopharmacology},
  year={2015},
  volume={27 1},
  pages={38-45}
}
NLRP3 inflammasome is engaged in the inflammatory response during acute lung injury (ALI). Purinergic receptor P2X7 has been reported to be upstream of NLRP3 activation. However, the therapeutic implication of P2X7 in ALI remains to be explored. The present study used lipopolysaccharide (LPS)-induced mouse model to investigate the therapeutic potential of P2X7 blockage in ALI. Our results showed that P2X7/NLRP3 inflammasome pathway was significantly upregulated in the lungs of ALI mice as… CONTINUE READING

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