Blockage of Mouse Muscle Nicotinic Receptors by Serotonergic Compounds

@article{GarcaColunga1999BlockageOM,
  title={Blockage of Mouse Muscle Nicotinic Receptors by Serotonergic Compounds},
  author={J. Garc{\'i}a-Colunga and R. Miledi},
  journal={Experimental Physiology},
  year={1999},
  volume={84}
}
Xenopus laevis oocytes were used to analyse the effects of serotonin (5‐hydroxytryptamine, 5‐HT) and serotonergic agents on ionic currents elicited by the activation of mammalian muscle nicotinic acetylcholine receptors (AChRs). 5‐HT as well as other serotonergic agents, such as ketanserin, 8‐hydroxy‐2‐(di‐n‐propylamino)tetralin (8‐OH‐DPAT), methysergide, spiperone, or fluoxetine alone (up to 1 mM), did not elicit membrane currents in Xenopus oocytes expressing AChRs, but they reversibly… Expand
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