Blockage of LMP1-modulated store-operated Ca(2+) entry reduces metastatic potential in nasopharyngeal carcinoma cell.

@article{Wei2015BlockageOL,
  title={Blockage of LMP1-modulated store-operated Ca(2+) entry reduces metastatic potential in nasopharyngeal carcinoma cell.},
  author={Jiazhang Wei and Jinyan Zhang and Yong-feng Si and Masamitsu Kanada and Zhe Zhang and Susumu Terakawa and Hiroshi Watanabe},
  journal={Cancer letters},
  year={2015},
  volume={360 2},
  pages={
          234-44
        }
}
Epstein-Barr virus (EBV)-encoded latent membrane proteins (LMPs) expedite progression of EBV-relevant cancers. Of the full set of LMPs, latent membrane protein 1 (LMP1) was identified to uniquely augment store-operated Ca(2+) entry (SOCE). Previously, we reported that the suppression of SOCE exhibited inhibitory effects on cell migration and the extravasation from vasculature in EBV-negative nasopharyngeal carcinoma (NPC) cells. In this follow-up study, we aimed to expand our understanding of… CONTINUE READING

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