Blockage of JAK/STAT signalling attenuates renal ischaemia-reperfusion injury in rat.

@article{Yang2008BlockageOJ,
  title={Blockage of JAK/STAT signalling attenuates renal ischaemia-reperfusion injury in rat.},
  author={Niansheng Yang and Mingqian Luo and Rong Li and Yuefang Huang and Rui Zhang and Qingqing Wu and Fang Wang and Youji Li and Xue-qing Yu},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2008},
  volume={23 1},
  pages={91-100}
}
BACKGROUND JAK/STAT signalling is one of the major pathways for cytokine signal transduction. However, the role of JAK/STAT in renal ischaemia/reperfusion (I/R) injury is not clear. The present study investigated the protection against renal I/R injury by in vivo inhibition of JAK2 activation. METHODS Rats subjected to renal I/R were either treated with… CONTINUE READING