Blockage of GSK3β-mediated Drp1 phosphorylation provides neuroprotection in neuronal and mouse models of Alzheimer's disease.

Abstract

It is well established that mitochondrial fragmentation plays a key role in the pathogenesis of Alzheimer's disease (AD). Mitochondrial fission is mediated by dynamin-related protein 1 (Drp1), which is highly expressed in nervous system and regulated by various posttranslational modifications including phosphorylation. We identified glycogen synthase kinase… (More)
DOI: 10.1016/j.neurobiolaging.2014.08.005

Topics

Cite this paper

@article{Yan2015BlockageOG, title={Blockage of GSK3β-mediated Drp1 phosphorylation provides neuroprotection in neuronal and mouse models of Alzheimer's disease.}, author={Jing Yan and Xiang-Hua Liu and Ming-Zhi Han and Yu-meng Wang and Xu-lu Sun and Nuo Yu and Ting Li and Bo Su and Zhe-yu Chen}, journal={Neurobiology of aging}, year={2015}, volume={36 1}, pages={211-27} }