Blockade of45Ca2+ influx through theN-methyl-d-aspartate receptor ion channel by the non-psychoactive cannabinoid HU-211

@article{Nadler1993BlockadeOI,
  title={Blockade of45Ca2+ influx through theN-methyl-d-aspartate receptor ion channel by the non-psychoactive cannabinoid HU-211},
  author={V. Nadler and R. Mechoulam and M. Sokolovsky},
  journal={Brain Research},
  year={1993},
  volume={622},
  pages={79-85}
}
The effects of the synthetic non-psychoactive cannabinoid (+)-(3S,4S)-7-hydroxy-delta 6-tetrahydrocannabinol 1,1-dimethylheptyl (HU-211) on the activity of the N-methyl-D-aspartate (NMDA) receptor/ion channel were examined. HU-211 non-competitively blocks the increase in binding of [3H]N-[1-(2-thienyl)-cyclohexyl]piperidine ([3H]TCP) induced by the polyamines spermine and spermidine or by glutamate and glycine. HU-211 does not, however, affect the direct binding of [3H]glycine and [3H]glutamate… Expand
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The non-psychotropic cannabinoid (+)-(3S,4S)-7-hydroxy-Δ6-tetrahydrocannabinol 1,1-dimethylheptyl (HU-211) attenuates N-methyl-d-aspartate receptor-mediated neurotoxicity in primary cultures of rat forebrain
  • 47
Interaction of dexanabinol (HU-211), a novel NMDA receptor antagonist, with the dopaminergic system.
  • 11
HU-211, a novel noncompetitive N-methyl-D-aspartate antagonist, improves neurological deficit and reduces infarct volume after reversible focal cerebral ischemia in the rat.
  • 100
Neuroprotective and antioxidant activities of HU-211, a novel NMDA receptor antagonist.
  • 85
Derivatives of Dexanabinol. I. Water-Soluble Salts of Glycinate Esters
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Post-ischemic administration of HU-211, a novel non-competitive NMDA antagonist, protects against blood-brain barrier disruption in photochemical cortical infarction in rats: a quantitative study
  • 38
Pharmacology of the intraocular pressure (IOP) lowering effect of systemic dexanabinol (HU-211), a non-psychotropic cannabinoid.
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Dexanabinol (HU‐211): A nonpsychotropic cannabinoid with neuroprotective properties
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The action of synthetic cannabinoids on the induction of long-term potentiation in the rat hippocampal slice.
  • 73
Endogenous Interleukin-1 Receptor Antagonist Mediates Anti-Inflammatory and Neuroprotective Actions of Cannabinoids in Neurons and Glia
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