Blockade of45Ca2+ influx through theN-methyl-d-aspartate receptor ion channel by the non-psychoactive cannabinoid HU-211

@article{Nadler1993BlockadeOI,
  title={Blockade of45Ca2+ influx through theN-methyl-d-aspartate receptor ion channel by the non-psychoactive cannabinoid HU-211},
  author={V. Nadler and R. Mechoulam and M. Sokolovsky},
  journal={Brain Research},
  year={1993},
  volume={622},
  pages={79-85}
}
The effects of the synthetic non-psychoactive cannabinoid (+)-(3S,4S)-7-hydroxy-delta 6-tetrahydrocannabinol 1,1-dimethylheptyl (HU-211) on the activity of the N-methyl-D-aspartate (NMDA) receptor/ion channel were examined. HU-211 non-competitively blocks the increase in binding of [3H]N-[1-(2-thienyl)-cyclohexyl]piperidine ([3H]TCP) induced by the polyamines spermine and spermidine or by glutamate and glycine. HU-211 does not, however, affect the direct binding of [3H]glycine and [3H]glutamate… Expand
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