Blockade of45Ca2+ influx through theN-methyl-d-aspartate receptor ion channel by the non-psychoactive cannabinoid HU-211

@article{Nadler1993BlockadeOI,
  title={Blockade of45Ca2+ influx through theN-methyl-d-aspartate receptor ion channel by the non-psychoactive cannabinoid HU-211},
  author={Varda Nadler and Raphael Mechoulam and Mordechai. Sokolovsky},
  journal={Brain Research},
  year={1993},
  volume={622},
  pages={79-85}
}
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The non-psychotropic cannabinoid (+)-(3S,4S)-7-hydroxy-Δ 6-tetrahydrocannabinol 1,1-dimethylheptyl (HU-211) attenuates N-methyl-d-aspartate receptor-mediated neurotoxicity in primary cultures of rat forebrain
Interaction of dexanabinol (HU-211), a novel NMDA receptor antagonist, with the dopaminergic system.
HU-211, a novel noncompetitive N-methyl-D-aspartate antagonist, improves neurological deficit and reduces infarct volume after reversible focal cerebral ischemia in the rat.
TLDR
Reversible MCAo with the use of a poly-L-lysine-coated intraluminal suture proved to be a reliable and effective modification of this technique, yielding consistent results.
Neuroprotective and antioxidant activities of HU-211, a novel NMDA receptor antagonist.
Derivatives of Dexanabinol. I. Water-Soluble Salts of Glycinate Esters
TLDR
The neuroprotecting properties manifested by some of the new derivatives were associated with very low neuronal cell toxicity and are credited to parent compound released by hydrolysis during the experiments rather than to intrinsic activity.
Post-ischemic administration of HU-211, a novel non-competitive NMDA antagonist, protects against blood-brain barrier disruption in photochemical cortical infarction in rats: a quantitative study
Pharmacology of the intraocular pressure (IOP) lowering effect of systemic dexanabinol (HU-211), a non-psychotropic cannabinoid.
TLDR
HU-211, administered i.v., is an effective IOP-lowering agent, devoid of any significant side effects (blood pressure, heart rate or pupil diameter, all of which have been reported previously for cannabinoids).
Dexanabinol (HU‐211): A nonpsychotropic cannabinoid with neuroprotective properties
TLDR
Results from experiments describing the potential use of HU‐211 as a neuroprotective agent in models of traumatic brain injury, stroke, optic nerve injury, pneumacocal meningitis, sepsis, and soman toxicity are discussed.
The action of synthetic cannabinoids on the induction of long-term potentiation in the rat hippocampal slice.
Endogenous Interleukin-1 Receptor Antagonist Mediates Anti-Inflammatory and Neuroprotective Actions of Cannabinoids in Neurons and Glia
TLDR
It is reported for the first time that both CB1 and CB2 receptors modulate release of endogenous IL-1ra from primary cultured glial cells, and this data suggest a novel neuroprotective mechanism of action for CBs in response to inflammatory or excitotoxic insults.
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