Blockade of voltage-gated sodium channels inhibits invasion of endocrine-resistant breast cancer cells

@inproceedings{Mohammed2016BlockadeOV,
  title={Blockade of voltage-gated sodium channels inhibits invasion of endocrine-resistant breast cancer cells},
  author={F Mohammed and Maitham A Khajah and Ming Yang and William J Brackenbury and Yunus A. Luqmani},
  booktitle={International journal of oncology},
  year={2016}
}
Voltage-gated Na+ channels (VGSCs) are membrane proteins which are normally expressed in excitable cells but have also been detected in cancer cells, where they are thought to be involved in malignancy progression. In this study we examined the ion current and expression profile of VGSC (Nav1.5) in estrogen receptor (ER)-positive (MCF-7) and silenced (pII) breast cancer cells and its possible influence on their proliferation, motility and invasion. VGSC currents were analysed by whole cell… CONTINUE READING