Blockade of very late antigen-4 integrin binding to fibronectin with connecting segment-1 peptide reduces accelerated coronary arteriopathy in rabbit cardiac allografts.

Abstract

Graft arteriopathy, a leading cause of cardiac allograft failure, is associated with increased intimal smooth muscle cells, inflammatory cells, and accumulation of extracellular matrix. We hypothesized that cellular fibronectin plays a pivotal role in the progression of the allograft arteriopathy by directing the transendothelial trafficking of inflammatory… (More)

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@article{Molossi1995BlockadeOV, title={Blockade of very late antigen-4 integrin binding to fibronectin with connecting segment-1 peptide reduces accelerated coronary arteriopathy in rabbit cardiac allografts.}, author={Silvana Molossi and M J Elices and Thomas Arrhenius and Ricardo Acosta Diaz and Claire Coulber and Marlene Rabinovitch}, journal={The Journal of clinical investigation}, year={1995}, volume={95 6}, pages={2601-10} }