Blockade of type I interferon (IFN) production by retroviral replicating vectors and reduced tumor cell responses to IFN likely contribute to tumor selectivity.

@article{Lin2014BlockadeOT,
  title={Blockade of type I interferon (IFN) production by retroviral replicating vectors and reduced tumor cell responses to IFN likely contribute to tumor selectivity.},
  author={Amy H-T Lin and Cindy Burrascano and Par L Pettersson and Carlos E. Iba{\~n}ez and Harry E. Gruber and Douglas J Jolly},
  journal={Journal of virology},
  year={2014},
  volume={88 17},
  pages={10066-77}
}
UNLABELLED We developed a Moloney mouse leukemia virus (MLV)-based retroviral replicating vector (RRV), Toca 511, which has displayed tumor specificity in resected brain tumor material and blood in clinical trials. Here, we investigated the interaction between Toca 511 and human host cells, and we show that RRVs do not induce type I interferon (IFN) responses in cultured human tumor cells or cultured human primary cells. However, exogenous type I IFN inhibited RRV replication in tumor cells and… CONTINUE READING
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