Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice.

@article{Arteaga1989BlockadeOT,
  title={Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice.},
  author={Carlos L. Arteaga and Libbey J. Kitten and Ester B. Coronado and Sabrina Jacobs and Frederick C. Kull and Donald Craig Allred and Charles Kent Osborne},
  journal={The Journal of clinical investigation},
  year={1989},
  volume={84 5},
  pages={
          1418-23
        }
}
Insulin and insulin-like growth factors (IGIs) stimulate the growth of human breast cancer cells in vitro. The type I somatomedin receptor (SR) expressed in these cells may mediate the growth effects of these peptides. We have examined the role of this receptor on human breast cancer growth with a monoclonal antibody (alpha-IR-3) that blocks the receptor binding domain and inhibits IGF-I-induced growth. alpha-IR-3 inhibited clonal growth in vitro and blocked the mitogenic effect of exogenous… CONTINUE READING
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