Blockade of the renin-angiotensin system improves cerebral microcirculatory perfusion in diabetic hypertensive rats.

@article{Estato2013BlockadeOT,
  title={Blockade of the renin-angiotensin system improves cerebral microcirculatory perfusion in diabetic hypertensive rats.},
  author={Vanessa Estato and Nathalie Obadia and Juliana Carvalho-Tavares and Felipe Santos Freitas and Patr{\'i}cia P. Reis and Hugo Caire Castro-Faria Neto and Marcos Adriano Lessa and Eduardo Tibiriç{\'a}},
  journal={Microvascular research},
  year={2013},
  volume={87},
  pages={41-9}
}
We examined the functional and structural microcirculatory alterations in the brain, skeletal muscle and myocardium of non-diabetic spontaneously hypertensive rats (SHR) and diabetic SHR (D-SHR), as well as the effects of long-term treatment with the angiotensin AT1-receptor antagonist olmesartan and the angiotensin-converting enzyme inhibitor enalapril. Diabetes was experimentally induced by a combination of a high-fat diet with a single low dose of streptozotocin (35 mg/kg, intraperitoneal… CONTINUE READING

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