Blockade of the pressor response to angiotensins I and II in the bullfrog, Rana catesbeiana.

@article{Harper1985BlockadeOT,
  title={Blockade of the pressor response to angiotensins I and II in the bullfrog, Rana catesbeiana.},
  author={Robert A. Harper and Gregory A. Stephens},
  journal={General and comparative endocrinology},
  year={1985},
  volume={60 2},
  pages={227-35}
}
We examined the effects of three angiotensin II (AII) analogs, [Sar1,Ala8] AII, [Sar1,Ile8] AII, and [Sar1,Thr8] AII, phenoxybenzamine and captopril on the pressor response to angiotensins I (AI) and II (AII) and norepinephrine (NE) in the bullfrog, Rana catesbeiana. Injection of AI and AII at 0.25, 0.5, and 1.0 micrograms/kg, or NE at 3 micrograms/kg elicited dose-dependent rises in blood pressure. [Sar1,Ile8] AII (10 micrograms/kg/min) significantly blocked the pressor effects of all AI and… CONTINUE READING