Blockade of the insulin-like growth factor I receptor in the choroid plexus originates Alzheimer's-like neuropathology in rodents: new cues into the human disease?

@article{Carro2006BlockadeOT,
  title={Blockade of the insulin-like growth factor I receptor in the choroid plexus originates Alzheimer's-like neuropathology in rodents: new cues into the human disease?},
  author={Eva Carro and Jos{\'e} Luis Trejo and Carlos Spuch and Delphine Bohl and Jean Michel Heard and Ign{\'a}cio Torres-Aleman},
  journal={Neurobiology of aging},
  year={2006},
  volume={27 11},
  pages={1618-31}
}
The possibility that perturbed insulin/insulin-like growth factor I (IGF-I) signalling is involved in development of late-onset forms of Alzheimer's disease (AD) is gaining increasing attention. We recently reported that circulating IGF-I participates in brain amyloid beta (Abeta) clearance by modulating choroid plexus function. We now present evidence that blockade of the IGF-I receptor in the choroid plexus originates changes in brain that are reminiscent of those found in AD. In rodents, IGF… CONTINUE READING
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