Blockade of the discriminative stimulus effects of d-amphetamine in rhesus monkeys with serotonin 5-HT(1A) agonists.

@article{Nader1994BlockadeOT,
  title={Blockade of the discriminative stimulus effects of d-amphetamine in rhesus monkeys with serotonin 5-HT(1A) agonists.},
  author={M A Nader and W S Woolverton},
  journal={Behavioural pharmacology},
  year={1994},
  volume={5 6},
  pages={591-598}
}
Rhesus monkeys (n = 4) were trained in a two-lever drug discrimination paradigm to discriminate d-amphetamine (AMPH; 0.56 or 1.0mg/kg, i.g., 60min pre-session) from saline. Lever pressing was maintained under a discrete-trials shock avoidance schedule of reinforcement (30 trials/day, 30-s intertrial interval, fixed-ratio 1). Before test sessions, in which responding on either lever avoided shock, the monkeys were infused (i.g.) with saline or various doses of AMPH (0.1-1.7mg/kg), alone or in… CONTINUE READING