Blockade of the Mineralocorticoid Receptor in Healthy Men: Effects on Experimentally Induced Panic Symptoms, Stress Hormones, and Cognition

@article{Otte2007BlockadeOT,
  title={Blockade of the Mineralocorticoid Receptor in Healthy Men: Effects on Experimentally Induced Panic Symptoms, Stress Hormones, and Cognition},
  author={Christian Otte and Steffen Moritz and Alexander Yassouridis and Maike Berit Koop and Ana Maria Madrischewski and Klaus Wiedemann and Michael Kellner},
  journal={Neuropsychopharmacology},
  year={2007},
  volume={32},
  pages={232-238}
}
Animal studies have shown that blockade of central mineralocorticoid receptors (MR) has anxiolytic effects and impairs several aspects of cognitive function. No study to date assessed the effects of MR blockade on anxiety and cognitive function in humans. In the present study, 16 healthy young men were treated either with placebo or with 300 mg spironolactone, a MR-antagonist, at 1100, 1330, and 1630 hours in a balanced cross-over design with the two study conditions being 1 week apart. At 1500… Expand
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TLDR
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