Blockade of swelling-induced chloride channels by phenol derivatives.

  title={Blockade of swelling-induced chloride channels by phenol derivatives.},
  author={Martin Gschwentner and Andreas Jungwirth and Sabine Hofer and Eichm{\"u}ller W{\"o}ll and Markus Ritter and Alfonso Susanna and Andreas Schmarda and Gilbert Reibnegger and Germar Michael Pinggera and Markus Leitinger and Julian Frick and Peter Deetjen and Markus Paulmichl},
  journal={British journal of pharmacology},
  volume={118 1},
1. In NIH3T3 fibroblasts, the chloride channel involved in regulatory volume decrease (RVD) was identified as ICln, a protein isolated from a cDNA library derived from Madin Darby canine Kidney (MDCK) cells. ICln expressed in Xenopus laevis oocytes gives rise to an outwardly rectifying chloride current, sensitive to the extracellular addition of nucleotides and the known chloride channel blockers, DIDS (4,4'-diisothiocyanatostilbene-2,2'-disulphonic acid) and NPPB (5-nitro-2-(3… CONTINUE READING