Blockade of substance P (neurokinin 1) receptors enhances extracellular serotonin when combined with a selective serotonin reuptake inhibitor: an in vivo microdialysis study in mice

@article{Guiard2004BlockadeOS,
  title={Blockade of substance P (neurokinin 1) receptors enhances extracellular serotonin when combined with a selective serotonin reuptake inhibitor: an in vivo microdialysis study in mice},
  author={B. Guiard and C. Przybylski and Jean-Philippe Guilloux and I. Seif and N. Froger and C. de Felipe and S. Hunt and L. Lanfumey and A. Gardier},
  journal={Journal of Neurochemistry},
  year={2004},
  volume={89}
}
  • B. Guiard, C. Przybylski, +6 authors A. Gardier
  • Published 2004
  • Medicine, Biology
  • Journal of Neurochemistry
  • Substance P antagonists of the neurokinin‐1 receptor type (NK1) are gaining growing interest as new antidepressant therapies. It has been postulated that these drugs exert this putative therapeutic effect without direct interactions with serotonin (5‐HT) neurones. Our recent microdialysis experiment performed in NK1 receptor knockout mice suggested evidence of changes in 5‐HT neuronal function ( Froger et al. 2001 ). The aim of the present study was to evaluate the effects of coadministration… CONTINUE READING

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 45 REFERENCES
    Sustained blockade of neurokinin-1 receptors enhances serotonin neurotransmission
    • 72
    Effect of neurokinin‐1 receptor antagonists on the function of 5‐HT and noradrenaline neurons
    • 45
    • Highly Influential