Blockade of substance P (neurokinin 1) receptors enhances extracellular serotonin when combined with a selective serotonin reuptake inhibitor: an in vivo microdialysis study in mice.

@article{Guiard2004BlockadeOS,
  title={Blockade of substance P (neurokinin 1) receptors enhances extracellular serotonin when combined with a selective serotonin reuptake inhibitor: an in vivo microdialysis study in mice.},
  author={Bruno P. Guiard and C{\'e}dric Przybylski and Jean-Philippe Guilloux and Isabelle Seif and Nicolas Froger and Carmen de Felipe and Stephen P. Hunt and Laurence Lanfumey and Alain Michel Gardier},
  journal={Journal of neurochemistry},
  year={2004},
  volume={89 1},
  pages={54-63}
}
Abstract Substance P antagonists of the neurokinin-1 receptor type (NK1) are gaining growing interest as new antidepressant therapies. It has been postulated that these drugs exert this putative therapeutic effect without direct interactions with serotonin (5-HT) neurones. Our recent microdialysis experiment performed in NK1 receptor knockout mice suggested evidence of changes in 5-HT neuronal function (Froger et al. 2001). The aim of the present study was to evaluate the effects of… CONTINUE READING

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