Corpus ID: 31452278

Blockade of responses of isolated myocardium to epinephrine.

@article{Nickerson1961BlockadeOR,
  title={Blockade of responses of isolated myocardium to epinephrine.},
  author={M. Nickerson and G. Chan},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1961},
  volume={133},
  pages={
          186-91
        }
}
  • M. Nickerson, G. Chan
  • Published 1961
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • The ability of various classical adrenergic blocking agents and of dichloroisoproterenol (DCI) to block the chronotropic and inotropic responses of the mammalian myocardium to epinephrine has been re-evaluated on isolated atria and papillary muscles. Maximum tolerated doses of Dibenamine, phenoxybenzamine (Dibenzyline), azapetine (Ilidar), piperoxan (933F, Benodaine), or Hydergine did not depress either response, except in preparations and under conditions in which a comparable decrease in… CONTINUE READING

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