Blockade of p53 by HIF-2α, but not HIF-1α, is involved in arsenite-induced malignant transformation of human bronchial epithelial cells

@article{Xu2012BlockadeOP,
  title={Blockade of p53 by HIF-2α, but not HIF-1α, is involved in arsenite-induced malignant transformation of human bronchial epithelial cells},
  author={Yuan Xu and Yuan Li and Ying Pang and Min Ling and L i Sh{\'e}n and Rongrong Jiang and Yongxi Zhao and Jianwei Zhou and Xinru Wang and Qizhan Liu},
  journal={Archives of Toxicology},
  year={2012},
  volume={86},
  pages={947-959}
}
Hypoxia-inducible factors (HIFs), which consist of α and β subunits, are transcription factors involved in regulation of a variety of cellular functions. By blocking the function of the tumor suppressor p53, over-expressions of HIFs are linked to carcinogenesis and tumor progression. Inorganic arsenic, a ubiquitous environmental contaminant, is associated with an increased risk of cancer. Although there are several hypotheses regarding arsenic-induced carcinogenesis, the mechanism of action… CONTINUE READING
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Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite

  • MC Duyndam, ST Hulscher, E van der Wall, HM Pinedo, E Boven
  • J Biol Chem
  • 2003
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