Blockade of nucleus accumbens opiate receptors attenuates intravenous heroin reward in the rat

@article{Vaccarino1985BlockadeON,
  title={Blockade of nucleus accumbens opiate receptors attenuates intravenous heroin reward in the rat},
  author={Franco J. Vaccarino and Floyd E. Bloom and George F. Koob},
  journal={Psychopharmacology},
  year={1985},
  volume={86},
  pages={37-42}
}
A quaternary derivative of naloxone, methyl naloxonium chloride (MN), was administered intracerebrally to rats trained to self-administer heroin intravenously. Increases in intravenous (IV) heroin self-administration rates were found following injections of low doses of MN into the nucleus accumbens (N.Acc), but not following injections of low doses of MN into the ventral tegmental area (VTA). These results were interpreted to suggest that the rewarding properties of IV heroin were decreased… CONTINUE READING

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