Blockade of nuclear factor-kappaB signaling pathway and anti-inflammatory activity of cardamomin, a chalcone analog from Alpinia conchigera.

@article{Lee2006BlockadeON,
  title={Blockade of nuclear factor-kappaB signaling pathway and anti-inflammatory activity of cardamomin, a chalcone analog from Alpinia conchigera.},
  author={J S Lee and Haeng Sun Jung and Phan Giang and Xuejun Jin and Sangku Lee and Phan Tong Son and Dongho Lee and Young-Soo Hong and Kyeong Sook Lee and Jung Joon Lee},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2006},
  volume={316 1},
  pages={271-8}
}
Nuclear factor-kappaB (NF-kappaB) and the signaling pathways that regulate its activity have become a focal point for intense drug discovery and development efforts. NF-kappaB regulates the transcription of a large number of genes, particularly those involved in immune, inflammatory, and antiapoptotic responses. In our search for NF-kappaB inhibitors from natural resources, we identified cardamomin, 2',4'-dihydroxy-6'-methoxychalcone, as an inhibitor of NF-kappaB activation from Alpinia… CONTINUE READING