Blockade of norepinephrine uptake and related activities of cis- and trans-N,N'-bis-(1-naphthylmethyl)-1,4-cyclohexane bis-(methylamine) dihydrochloride.

@article{Lippmann1970BlockadeON,
  title={Blockade of norepinephrine uptake and related activities of cis- and trans-N,N'-bis-(1-naphthylmethyl)-1,4-cyclohexane bis-(methylamine) dihydrochloride.},
  author={W. Lippmann},
  journal={Biochemical pharmacology},
  year={1970},
  volume={19 5},
  pages={
          1709-17
        }
}
  • W. Lippmann
  • Published 1970
  • Chemistry, Medicine
  • Biochemical pharmacology
Abstract The effects of cis - (C; AY-20,552) and trans- (T; AY-20,553) N , N ′-bis (1-naphthylmethyl)-1,4-cyclohexane bis (methylamine) dihydrochloride on the uptake and storage of the monoamines and their related properties were determined. Both compounds reduced the 3 H-norepinephrine ( 3 H-NE) in the mouse and rat heart when given before, but not after, the 3 H-NE; T was more potent in its action. The uptake activity was largely recovered by 7 hr after C, 16 hr after T or imipramine, and 24… Expand

References

SHOWING 1-10 OF 21 REFERENCES
Blockade of norepinephrine uptake by N,N'-bis-(1-naphthylmethyl)-1,4-cyclohexane bis-(methylamine) dihydrochloride in rodents.
  • W. Lippmann
  • Chemistry, Medicine
  • Biochemical pharmacology
  • 1969
TLDR
Of 45 structurally related compounds studies, AY-9928 was the most potent in causing a decrease in the 3H-norepinephrine in the mouse heart when given before, but not after, the 3 H-norespinephrine. Expand
Effect of Drugs on the Uptake and Release of 3H-Norepinephrine in the Rat Heart
TLDR
A lower concentration of injected 3H-noradrenaline was found in the heart, spleen and adrenal glands than usual following the administration of psychoactive agents and sympathomimetic amines. Expand
Effect of drugs on the uptake and metabolism of H3-norepinephrine.
TLDR
The catechol-O-methyl transferase inhibitor, pyrogallol, elevated the concentration of H 3 - norepinephrine in heart, spleen, liver and muscle but not the adrenal gland and plasma, and lowered the concentration in these tissues except the heart and spleen. Expand
ANTAGONISM OF CERTAIN EFFECTS OF CATECHOLAMINE-DEPLETING AGENTS BY ANTIDEPRESSANT AND RELATED DRUGS.
TLDR
In terms of potency, protriptyline proved to be the most active antagonist of the several agents studied, both in terms of preventing catecholamine depletion and antagonizing the neuron blocking action of guanethidine. Expand
Inhibition of Uptake of Tritiated-noradrenaline in the Intact Rat Brain by Imipramine and Structurally Related Compounds
TLDR
A procedure which made it possible to introduce tritiated-noradrenaline of high specific activity into the rat brain by an intraventricular injection is described and it will be shown that imipramine and structurally related antidepressant drugs but not chlorpromazine block the uptake of tritiates in the brain. Expand
THE ACTION OF DESMETHYLIMIPRAMINE IN COUNTERACTING SEDATION AND CHOLINERGIC EFFECTS OF RESERPINE-LIKE DRUGS
Desmethylimipramine (DMI), a major metabolite of imipramine, elicits no obvious pharmacological effects of its own but, in doses comparable to those used to treat primary depression in man, preventsExpand
Inhibition of noradrenaline uptake by drugs
TLDR
The present study was undertaken as a quantitative investigation of the potencies of cocaine, reserpine, guanethidine, imipramine, chlorpromazine and the adrenergic blocking agents dichloroisoprenaline, ergotamine and phenoxybenzamine as inhibitors of noradrenaline uptake. Expand
The fate of H3-norepinephrine in animals.
TLDR
The importance of binding as a mechanism for the inactivation of circulating catecholamines is emphasized, and it is shown to be quantitatively more important for norepinephrine than for epinephrine. Expand
Chlorpromazine. III. The effects of chlorpromazine and chlorpromazine sulfoxide on vascular responses to L-epinephrine and levarterenol.
TLDR
It has been proposed that chiorpromazine has two dissociable actions on epinephrine and levarterenol; it blocks the adrenergic receptor and depresses some deactivating process. Expand
Effects of catecholamines on lipid metabolism.
  • M. Wenke
  • Chemistry, Medicine
  • Advances in lipid research
  • 1966
TLDR
It is surprising that it is not possible to find the known quantitative differences in action, typical for a muscular β function in the three main catecholamines, which agree extremely well with those for muscular β effects. Expand
...
1
2
3
...