Blockade of noradrenaline transport abolishes 4-methylthioamphetamine-induced contraction of the rat aorta in vitro.

@article{Quinn2006BlockadeON,
  title={Blockade of noradrenaline transport abolishes 4-methylthioamphetamine-induced contraction of the rat aorta in vitro.},
  author={Stephen T. Quinn and Patrick J. Guiry and Thomas R. Schwab and Alan K. Keenan and G J McBean},
  journal={Autonomic \& autacoid pharmacology},
  year={2006},
  volume={26 4},
  pages={
          335-44
        }
}
The aim of this study was to characterize the effects of 4-methylthioamphetamine (4-MTA) on contractility and noradrenaline (NA) transport and release in the isolated rat aorta. Descending thoracic aortic rings were isolated from male Wistar rats (220-240 g) and the effect of 4-MTA on contractility was measured by isometric force displacement. 4-MTA (0.1 microm-1 mm) induced a concentration-dependent contraction of aortic rings, with a pD(2) of 4.40 +/- 0.38, and an E(max) of 0.80 +/- 0.05 g… 
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