Blockade of nonhormonal fibroblast growth factors by FP-1039 inhibits growth of multiple types of cancer.

@article{Harding2013BlockadeON,
  title={Blockade of nonhormonal fibroblast growth factors by FP-1039 inhibits growth of multiple types of cancer.},
  author={Thomas C. Harding and Li Tsz Long and Servando Palencia and Hongbing Zhang and Ali Sadra and Kevin Hestir and Namrata T Patil and Anita Levin and Amy W Hsu and Deborah H Charych and Thomas E. Brennan and James A. Zanghi and Robert Halenbeck and Shannon A Marshall and Minmin Qin and Stephen K. Doberstein and Diane L Hollenbaugh and W. Michael Kavanaugh and Lewis T. Williams and Kevin P. Baker},
  journal={Science translational medicine},
  year={2013},
  volume={5 178},
  pages={178ra39}
}
The fibroblast growth factor (FGF) pathway promotes tumor growth and angiogenesis in many solid tumors. Although there has long been interest in FGF pathway inhibitors, development has been complicated: An effective FGF inhibitor must block the activity of multiple mitogenic FGF ligands but must spare the metabolic hormone FGFs (FGF-19, FGF-21, and FGF-23) to avoid unacceptable toxicity. To achieve these design requirements, we engineered a soluble FGF receptor 1 Fc fusion protein, FP-1039. FP… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Related Discussions
This paper has been referenced on Twitter 24 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 38 extracted citations

FGFR1 mRNA and protein expression, not gene copy number, predict FGFR TKI sensitivity across all lung cancer histologies.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2014
View 7 Excerpts
Highly Influenced

Specific Antibody Fragment Ligand Traps Blocking FGF1 Activity

International journal of molecular sciences • 2018
View 5 Excerpts
Highly Influenced

A novel decoy receptor fusion protein for FGF-2 potently inhibits tumour growth

British Journal of Cancer • 2014
View 4 Excerpts
Highly Influenced

Genomic aberrations in the FGFR pathway: opportunities for targeted therapies in solid tumors.

Annals of oncology : official journal of the European Society for Medical Oncology • 2014
View 3 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 44 references

Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome.

Proceedings of the National Academy of Sciences of the United States of America • 2001
View 10 Excerpts
Highly Influenced

Molecular profiles of EGFR , Kras , c - met , and FGFR in pulmonary www . Scien pleomorphic carcinoma , a rare lung malignancy

Y. Kim, J. M. Sun, +7 authors M. J. Ahn
J . Cancer Res . Clin . Oncol . • 2011

Similar Papers

Loading similar papers…