Blockade of nonhormonal fibroblast growth factors by FP-1039 inhibits growth of multiple types of cancer.

  title={Blockade of nonhormonal fibroblast growth factors by FP-1039 inhibits growth of multiple types of cancer.},
  author={Thomas C. Harding and Li Tsz Long and Servando Palencia and Hongbing Zhang and Ali Sadra and Kevin Hestir and Namrata T Patil and Anita Levin and Amy W Hsu and Deborah H Charych and Thomas E. Brennan and James A. Zanghi and Robert Halenbeck and Shannon A Marshall and Minmin Qin and Stephen K. Doberstein and Diane L Hollenbaugh and W. Michael Kavanaugh and Lewis T. Williams and Kevin P. Baker},
  journal={Science translational medicine},
  volume={5 178},
The fibroblast growth factor (FGF) pathway promotes tumor growth and angiogenesis in many solid tumors. Although there has long been interest in FGF pathway inhibitors, development has been complicated: An effective FGF inhibitor must block the activity of multiple mitogenic FGF ligands but must spare the metabolic hormone FGFs (FGF-19, FGF-21, and FGF-23) to avoid unacceptable toxicity. To achieve these design requirements, we engineered a soluble FGF receptor 1 Fc fusion protein, FP-1039. FP… CONTINUE READING
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