Blockade of neutrophil responses in aspiration pneumonia via ELR-CXC chemokine antagonism does not predispose to airway bacterial outgrowth.

@article{Zhao2010BlockadeON,
  title={Blockade of neutrophil responses in aspiration pneumonia via ELR-CXC chemokine antagonism does not predispose to airway bacterial outgrowth.},
  author={Xixing Zhao and Jennifer R. Town and Fang Li and Wei Li and Xiaobei Zhang and John R. M. Gordon},
  journal={Pulmonary pharmacology & therapeutics},
  year={2010},
  volume={23 1},
  pages={22-8}
}
Pneumonia associated with aspiration of bacterial-laden gastric contents is characterized by Glu-Leu-Arg (ELR)-CXC chemokine (e.g., CXC2L1, CXCL8) expression leading to local neutrophil sequestration. This neutrophil response is designed to be protective, but overly aggressive responses can be pathogenic in themselves. Herein we assessed whether blocking neutrophil responses in a guinea pig model of aspiration pneumonia would foster airway bacterial growth. Guinea pigs (n=5) were challenged… CONTINUE READING
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