Blockade of neuronal facilitatory nicotinic receptors containing alpha 3 beta 2 subunits contribute to tetanic fade in the rat isolated diaphragm.

@article{Faria2003BlockadeON,
  title={Blockade of neuronal facilitatory nicotinic receptors containing alpha 3 beta 2 subunits contribute to tetanic fade in the rat isolated diaphragm.},
  author={Miguel A. Faria and Laura Oliveira and Maria Alexandrina Tim{\'o}teo and M. Graça B. Lobo and Paulo Correia-de-S{\'a}},
  journal={Synapse},
  year={2003},
  volume={49 2},
  pages={77-88}
}
Nicotinic receptor (nAChR) subtypes involved in pre- and postjunctional actions underlying tetanic fade were studied in rat phrenic-nerve hemidiaphragms. We investigated the ability of subtype-specific nAChR antagonists to depress nerve-evoked contractions and [(3)H]-acetylcholine ([(3)H]-ACh) release. Muscle tension was transiently increased during brief high frequency trains (50 Hz for 5 sec). The rank potency order of nAChR antagonists to reduce tetanic peak tension was alpha-bungarotoxin… CONTINUE READING