Blockade of muscarinic acetylcholine receptors facilitates motivated behaviour and rescues a model of antipsychotic-induced amotivation

@article{Hailwood2018BlockadeOM,
  title={Blockade of muscarinic acetylcholine receptors facilitates motivated behaviour and rescues a model of antipsychotic-induced amotivation},
  author={Jonathan M Hailwood and Christopher J Heath and Benjamin U. Phillips and Trevor William Robbins and Lisa M. Saksida and Timothy J. Bussey},
  journal={Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  year={2018}
}
Disruptions to motivated behaviour are a highly prevalent and severe symptom in a number of neuropsychiatric and neurodegenerative disorders. Current treatment options for these disorders have little or no effect upon motivational impairments. We assessed the contribution of muscarinic acetylcholine receptors to motivated behaviour in mice, as a novel pharmacological target for motivational impairments. Touchscreen progressive ratio (PR) performance was facilitated by the nonselective… Expand
11 Citations
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