Blockade of macrophage autophagy ameliorates activated lymphocytes-derived DNA induced murine lupus possibly via inhibition of proinflammatory cytokine production.

@article{Li2014BlockadeOM,
  title={Blockade of macrophage autophagy ameliorates activated lymphocytes-derived DNA induced murine lupus possibly via inhibition of proinflammatory cytokine production.},
  author={Baihui Li and Yan Yue and Chunsheng Dong and Yongbing Shi and Sidong Xiong},
  journal={Clinical and experimental rheumatology},
  year={2014},
  volume={32 5},
  pages={705-14}
}
OBJECTIVES Systemic lupus erythematosus (SLE) is a typical inflammatory autoimmune disease for its unknown pathogenesis and potential fatality. It has been reported that autophagy has a crosstalk with autoimmunity, but its impact on the pathogenesis of SLE remains unclear. Here, we investigated the role of autophagy in inflammatory response of macrophages under SLE conditions. METHODS First, we detected the expression of autophagy-related genes (Atg5, Atg12 and Beclin 1) in the macrophages… CONTINUE READING
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