Blockade of long-term depression in neonatal hippocampal slices by a phospholipase A2 inhibitor.

@article{Fitzpatrick1994BlockadeOL,
  title={Blockade of long-term depression in neonatal hippocampal slices by a phospholipase A2 inhibitor.},
  author={John S. Fitzpatrick and Michel Baudry},
  journal={Brain research. Developmental brain research},
  year={1994},
  volume={78 1},
  pages={81-6}
}
Low-frequency stimulation of the Schaffer-commissural pathways in slices prepared from juvenile rats (postnatal day 10-15) results in a long-term depression (LTD) of synaptic transmission. 30 min after 5 min of stimulation at 5 Hz, the response to the stimulated pathway was decreased by 36%, whereas the response to an unstimulated pathway projecting to the same neuronal population was decreased by 20%. Stimulation in the presence of the NMDA receptor antagonist AP5 completely prevented… CONTINUE READING

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