Blockade of lithium chloride-induced conditioned place aversion as a test for antiemetic agents: comparison of metoclopramide with combined extracts of Zingiber officinale and Ginkgo biloba.

@article{Frisch1995BlockadeOL,
  title={Blockade of lithium chloride-induced conditioned place aversion as a test for antiemetic agents: comparison of metoclopramide with combined extracts of Zingiber officinale and Ginkgo biloba.},
  author={Christian Frisch and R{\"u}diger U Hasen{\"o}hrl and Christel Mattern and Rolf H{\"a}cker and Joseph P. Huston},
  journal={Pharmacology, biochemistry, and behavior},
  year={1995},
  volume={52 2},
  pages={321-7}
}
The present study tests the hypothesis that the blockade of lithium chloride-induced conditioned place aversion might be a suitable model to assess antiemetic properties of drugs, especially in species that do not vomit, like rats. The effects of the known antiemetic compound metoclopramide were compared with those of zingicomb, a combination preparation of extracts of Ginkgo biloba and Zingiber officinale, also presumed to have antiemetic properties. Place conditioning was performed using a… CONTINUE READING

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