Blockade of lipid accumulation by silibinin in adipocytes and zebrafish.

  title={Blockade of lipid accumulation by silibinin in adipocytes and zebrafish.},
  author={Hyung Joo Suh and So Young Cho and Eun Young Kim and Hyeon-Son Choi},
  journal={Chemico-biological interactions},
Silibinin is a compound present mainly in milk thistle. In this study, we investigated the mechanism by which silibinin suppresses adipogenesis of 3T3-L1 cells, and evaluated the anti-adipogenic effect of silibinin in zebrafish. Silibinin reduced lipid accumulation by downregulating adipogenic factors, such as, peroxisome proliferator-activated receptor γ (PPARγ), CCAAT-enhancer binding protein α (C/EBPα), and fatty acid-binding protein 4 (FABP4). The reduction of these adipogenic protein… CONTINUE READING


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