Blockade of insulin-like growth factor I receptor function inhibits growth and angiogenesis of colon cancer.

@article{Reinmuth2002BlockadeOI,
  title={Blockade of insulin-like growth factor I receptor function inhibits growth and angiogenesis of colon cancer.},
  author={Niels Reinmuth and Wenbiao Liu and Fan Fan and Young Do Jung and Syed A. Ahmad and Oliver Stoeltzing and Corazon D. Bucana and Robert R Radinsky and Lee M. Ellis},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2002},
  volume={8 10},
  pages={3259-69}
}
PURPOSE AND EXPERIMENTAL DESIGN Insulin-like growth factors (IGFs) I and II and their principle receptor, IGF-I receptor (IGF-IR), are frequently expressed in human colon cancers and play a role in preventing apoptosis, enhancing cell proliferation, and inducing expression of vascular endothelial growth factor (VEGF). To elucidate the in vitro and in vivo effects of IGF-IR in human colon cancer growth and angiogenesis, HT29 cells were transfected with a truncated dominant-negative (DN) form of… CONTINUE READING