Blockade of histamine H2 receptors protects the heart against ischemia and reperfusion injury in dogs.

@article{Asanuma2006BlockadeOH,
  title={Blockade of histamine H2 receptors protects the heart against ischemia and reperfusion injury in dogs.},
  author={Hiroshi Asanuma and Tetsuo Minamino and Akiko Ogai and Jiyoong Kim and Masanori Asakura and Kazuo Komamura and Shoji Sanada and M. Fujita and Akio Hirata and Masakatsu Wakeno and Osamu Tsukamoto and Yoshiro Shinozaki and Masafumi Myoishi and Seiji Takashima and Hitonobu Tomoike and Masafumi Kitakaze},
  journal={Journal of molecular and cellular cardiology},
  year={2006},
  volume={40 5},
  pages={666-74}
}
We have previously reported that histamine H(2) blockers may be cardioprotective in patients with chronic heart failure. Since both endogenous histamine and histamine H(2) receptors are present in heart tissue, we tested the hypothesis that the blockade of histamine H(2) receptors mediates protection against reversible or irreversible ischemia and reperfusion injury. In open-chest dogs, the left anterior descending coronary artery was occluded for 90 minutes, followed by reperfusion for 6 hours… CONTINUE READING