Blockade of hippocampal nicotinic receptors impairs working memory but not reference memory in rats.

@article{Ohno1993BlockadeOH,
  title={Blockade of hippocampal nicotinic receptors impairs working memory but not reference memory in rats.},
  author={Mizuki Ohno and Tsuneyuki Yamamoto and Shigenori Watanabe},
  journal={Pharmacology, biochemistry, and behavior},
  year={1993},
  volume={45 1},
  pages={89-93}
}
In a three-panel runway task, intrahippocampal injection of the nicotinic receptor antagonist, mecamylamine (10 and 18 micrograms/side), significantly increased the number of errors (attempts to pass through two incorrect panels of the three panel-gates at four choice points) in a test of working memory. This increase in errors also occurred after rats were given IP mecamylamine (10 mg/kg). Mecamylamine did not affect the number of errors in a test of reference memory whether it was given at… CONTINUE READING

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