Blockade of gamma-aminobutyric acid-gated chloride current in frog sensory neurons by picrotoxin.

@article{Inoue1988BlockadeOG,
  title={Blockade of gamma-aminobutyric acid-gated chloride current in frog sensory neurons by picrotoxin.},
  author={Masumi Inoue and Norio Akaike},
  journal={Neuroscience research},
  year={1988},
  volume={5 5},
  pages={380-94}
}
The mechanism of picrotoxin (PTX) suppression of the gamma-aminobutyric acid (GABA)-gated Cl- current (ICl) was examined in frog sensory neurons using the 'concentration-clamp' technique. The activation phase of GABA-induced ICl showed little change with the concomitant application of 10(-5) M PTX; however, the inactivation phase was markedly facilitated. ICl produced by simultaneous application of GABA and PTX was non-competitively suppressed while the plateau current showed a mixed type of… CONTINUE READING

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