Blockade of endothelial enzymes: new therapeutic targets

  title={Blockade of endothelial enzymes: new therapeutic targets},
  author={Patricio L{\'o}pez-Jaramillo and Juan P. Casas},
  journal={Journal of Human Hypertension},
Nitric oxide (NO) is the principal vasoactive substance produced by the vascular endothelium with antitrombotic, antiatherogenic and vasodilator actions. The loss of these functions is now known as endothelial dysfunction (ED) and it has been proposed that it is the final common pathway in cardiovascular disease. At the moment there is an important body of evidence that supports the proposal that ED is a consequence of an imbalance between the free radicals, NO, superoxide (O−2) and… CONTINUE READING