Blockade of effects of smoked marijuana by the CB1-selective cannabinoid receptor antagonist SR141716.

@article{Huestis2001BlockadeOE,
  title={Blockade of effects of smoked marijuana by the CB1-selective cannabinoid receptor antagonist SR141716.},
  author={Marilyn A Huestis and David Alan Gorelick and Stephen J. Heishman and Kenzie L Preston and Richard Andrew Nelson and Eric T Moolchan and Richard A Frank},
  journal={Archives of general psychiatry},
  year={2001},
  volume={58 4},
  pages={322-8}
}
BACKGROUND SR141716, a recently developed CB1 cannabinoid receptor antagonist, blocks acute effects of Delta-9-tetrahydrocannabinol (THC) and other CB1 cannabinoid agonists in vitro and in animals. These findings suggest that CB1 receptors mediate many of the effects of marijuana, but this has not been evaluated in humans. METHODS Sixty-three healthy men with a history of marijuana use were randomly assigned to receive oral SR141716 or a placebo in an escalating dose (1, 3, 10, 30, and 90 mg… CONTINUE READING