Blockade of delta opioid receptors in the ventrolateral periaqueductal gray region inhibits the fall in arterial pressure evoked by hemorrhage.

@article{Cavun2001BlockadeOD,
  title={Blockade of delta opioid receptors in the ventrolateral periaqueductal gray region inhibits the fall in arterial pressure evoked by hemorrhage.},
  author={Sinan Cavun and Garth E. Resch and A D Evec and M M Rapacon-Baker and William R. Millington},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2001},
  volume={297 2},
  pages={612-9}
}
Severe hemorrhage lowers arterial pressure by suppressing sympathetic activity. The central mechanism that initially triggers the fall in arterial pressure evoked by hemorrhage is not well understood, although opioid neurons are thought to play a role. This study tested the hypothesis that hemorrhagic hypotension is mediated by delta opioid receptors in the ventrolateral periaqueductal gray (vlPAG), a region importantly involved in opioid analgesia. Depressor sites were first identified by… CONTINUE READING

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