Blockade of chloride channels reveals relaxations of rat small mesenteric arteries to raised potassium.

@article{Doughty2001BlockadeOC,
  title={Blockade of chloride channels reveals relaxations of rat small mesenteric arteries to raised potassium.},
  author={Joanne M. Doughty and John P Boyle and Philip D. Langton},
  journal={British journal of pharmacology},
  year={2001},
  volume={132 1},
  pages={293-301}
}
1. Raised extracellular K(+) relaxes some arteries, and has been proposed as Endothelium-Derived Hyperpolarizing Factor (EDHF). However, relaxation of rat small mesenteric arteries to K(+) is highly variable. We have investigated the mechanism of K(+)-induced dilatation and relaxation of pressurized arteries and arteries mounted for measurement of isometric force. 2. Raising [K(+)](o) from 5.88 - 10.58 mM did not dilate or relax pressurized or isometric arteries. Relaxation to raised [K(+)](o… CONTINUE READING

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