Blockade of central nicotine acetylcholine receptor signaling attenuate ghrelin-induced food intake in rodents.


Here we sought to determine whether ghrelin's central effects on food intake can be interrupted by nicotine acetylcholine receptor (nAChR) blockade. Ghrelin regulates mesolimbic dopamine neurons projecting from the ventral tegmental area (VTA) to the nucleus accumbens, partly via cholinergic VTA afferents originating in the laterodorsal tegmental area (LDTg… (More)
DOI: 10.1016/j.neuroscience.2010.10.005