Blockade of capacitive Ca2+ influx by Cl- channel blockers inhibits secretion from rat mucosal-type mast cells.

@article{Reinsprecht1995BlockadeOC,
  title={Blockade of capacitive Ca2+ influx by Cl- channel blockers inhibits secretion from rat mucosal-type mast cells.},
  author={M Reinsprecht and Michael Rohn and R J Spadinger and Israel Pecht and Hansgeorg Schindler and Christoph Romanin},
  journal={Molecular pharmacology},
  year={1995},
  volume={47 5},
  pages={1014-20}
}
Whole-cell patch-clamp recordings of membrane currents were performed in combination with measurements of mediator secretion from mucosal-type mast cells (rat basophilic leukemia cells, subline 2H3), to determine the involvement of membrane conductances induced upon depletion of intracellular Ca2+ stores. In patch-clamp experiments, ethylene glycol bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid-induced depletion of internal Ca2+ stores led to activation of two distinct membrane… CONTINUE READING