Blockade of cannabinoid receptor 1 improves insulin resistance, lipid metabolism, and diabetic nephropathy in db/db mice.

@article{Nam2012BlockadeOC,
  title={Blockade of cannabinoid receptor 1 improves insulin resistance, lipid metabolism, and diabetic nephropathy in db/db mice.},
  author={Deok Hwa Nam and Mi Hwa Lee and Jung Eun Kim and Hye Kyoung Song and Young Sun Kang and Jae Eun Lee and Hyeong Wook Kim and Jin Joo Cha and Young Youl Hyun and Sung Hoon Kim and Sang Youb Han and Kum Hyun Han and Jee Young Han and Dae Ryong Cha},
  journal={Endocrinology},
  year={2012},
  volume={153 3},
  pages={1387-96}
}
The endocannabinoid system is important in the pathogenesis of obesity-related metabolic disorders. However, the effect of inhibiting the endocannabinoid system in type 2 diabetic nephropathy is unclear. Therefore, we examined the effect of the cannabinoid (CB)1 receptor antagonist, SR141716, on insulin resistance and diabetic nephropathy in db/db mice. Six-week-old db/db mice were treated with the CB1-specific antagonist SR141716 (10 mg/kg · d) for 3 months. Treatment with SR141716… CONTINUE READING
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