Blockade of calpain proteolytic activity rescues neurons from glutamate excitotoxicity.

@article{Rami1997BlockadeOC,
  title={Blockade of calpain proteolytic activity rescues neurons from glutamate excitotoxicity.},
  author={A Rami and Dr. W. Ferger and Josef Krieglstein},
  journal={Neuroscience research},
  year={1997},
  volume={27 1},
  pages={93-7}
}
The potential of protease inhibitors E-64, calpain inhibitor I (CPI-I) and MDL28170 to protect hippocampal neurons in an in vitro model of neurotoxicity was investigated. Hippocampal cultures were treated with glutamate, and neurotoxicity was quantified. Glutamate treated cultures exhibited damage to approximately 50% of neurons. In contrast only 20-30% of neurons were damaged in cultures treated with glutamate and calpain inhibitors. E-64 and CPI-I are capable of protecting neurons from injury… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

Similar Papers

Loading similar papers…