Blockade of calcium-permeable AMPA receptors protects hippocampal neurons against global ischemia-induced death.

@article{Noh2005BlockadeOC,
  title={Blockade of calcium-permeable AMPA receptors protects hippocampal neurons against global ischemia-induced death.},
  author={Kyung-min Noh and Hidenori Yokota and Toshihiro Mashiko and Pablo E Castillo and R Suzanne Zukin and Michael V. L. Bennett},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 34},
  pages={12230-5}
}
Transient global or forebrain ischemia induced experimentally in animals can cause selective, delayed neuronal death of hippocampal CA1 pyramidal neurons. A striking feature is a delayed rise in intracellular free Zn(2+) in CA1 neurons just before the onset of histologically detectable cell death. Here we show that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) at Schaffer collateral to CA1 synapses in postischemic hippocampus exhibit… CONTINUE READING
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